Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy
Por um escritor misterioso
Last updated 16 junho 2024
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Introduction Syndecans are heparan sulphate proteoglycans expressed by endothelial cells. Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a role in leukocyte trafficking. The objective of the current study was to examine the function of syndecan-3 in joint inflammation by genetic deletion in mice and compare with other tissues. Methods Chemokine C-X-C ligand 1 (CXCL1) was injected in the joints of syndecan-3−/−and wild-type mice and antigen-induced arthritis performed. For comparison chemokine was administered in the skin and cremaster muscle. Intravital microscopy was performed in the cremaster muscle. Results Administration of CXCL1 in knee joints of syndecan-3−/−mice resulted in reduced neutrophil accumulation compared to wild type. This was associated with diminished presence of CXCL1 at the luminal surface of synovial endothelial cells where this chemokine clustered and bound to heparan sulphate. Furthermore, in the arthritis model syndecan-3 deletion led to reduced joint swelling, leukocyte accumulation, cartilage degradation and overall disease severity. Conversely, CXCL1 administration in the skin of syndecan-3 null mice provoked increased neutrophil recruitment and was associated with elevated luminal expression of E-selectin by dermal endothelial cells. Similarly in the cremaster, intravital microscopy showed increased numbers of leukocytes adhering and rolling in venules in syndecan-3−/−mice in response to CXCL1 or tumour necrosis factor alpha. Conclusions This study shows a novel role for syndecan-3 in inflammation. In the joint it is selectively pro-inflammatory, functioning in endothelial chemokine presentation and leukocyte recruitment and cartilage damage in an RA model. Conversely, in skin and cremaster it is anti-inflammatory.
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://www.ahajournals.org/cms/asset/7f7a3ee4-402f-4ee3-b1ef-7be916b1a745/2ff4.jpeg)
Syndecans Circulation Research
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Leukocyte migration after intradermal injection of CXCL1 in sdc-3 null
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://journals.physiology.org/cms/10.1152/ajpcell.00086.2022/asset/images/medium/ajpcell.00086.2022_f002.gif)
Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis
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Biological role of matrix metalloproteinases: a critical balance
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://www.frontiersin.org/files/Articles/1078350/fmed-09-1078350-HTML/image_m/fmed-09-1078350-g001.jpg)
Frontiers Interleukin-34-regulated T-cell responses in rheumatoid arthritis
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Rheumatoid Arthritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
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Syndecan-3: A Signaling Conductor in the Musculoskeletal System
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://www.mdpi.com/ijms/ijms-22-11592/article_deploy/html/images/ijms-22-11592-g001.png)
IJMS, Free Full-Text
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://pubs.acs.org/cms/10.1021/acsomega.2c00619/asset/images/large/ao2c00619_0010.jpeg)
Sarcococca saligna Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund's Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://www.ahajournals.org/cms/asset/3a8a7c56-3d87-4dd2-8c1d-bf7ec20cf127/2ff1.jpg)
Syndecans Circulation Research
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://iiif.elifesciences.org/lax:78085%2Felife-78085-fig10-v1.tif/full/1500,/0/default.jpg)
Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F978-3-030-73453-4_7/MediaObjects/479640_1_En_7_Fig4_HTML.png)
Syndecan-3: A Signaling Conductor in the Musculoskeletal System
![Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2Far4610/MediaObjects/13075_2014_Article_4236_Fig3_HTML.jpg)
Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice, Arthritis Research & Therapy
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